Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions. A systematic review
Med. oral patol. oral cir. bucal (Internet)
; 21(2): e250-e259, mar. 2016. tab, graf
Article
in En
| IBECS
| ID: ibc-151072
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Special Patients Unit. Medical-Surgical Dental Research Group (OMEQUI).. (Spain) BACKGROUND:
A study was made to identify the most effective protocol for reducing the risk of osteonecrosis of the jaws (ONJ) following tooth extraction in patients subjected to treatment with antiresorptive or antiangiogenic drugs. MATERIAL ANDMETHODS:
A MEDLINE and SCOPUS search (January 2003 - March 2015) was made with the purpose of conducting a systematic literature review based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. All articles contributing information on tooth extractions in patients treated with oral or intravenous antiresorptive or antiangiogenic drugs were included.RESULTS:
Only 13 of the 380 selected articles were finally included in the review 11 and 5 of them offered data on patients treated with intravenous and oral bisphosphonates, respectively. No randomized controlled trials were found - all publications corresponding to case series or cohort studies. The prevalence of ONJ in the patients treated with intravenous and oral bisphosphonates was 6,9% (range 0-34.7%) and 0.47% (range 0-2.5%), respectively. The main preventive measures comprised local and systemic infection control.CONCLUSIONS:
No conclusive scientific evidence is available to date on the efficacy of ONJ prevention protocols in patients treated with antiresorptive or antiangiogenic drugs subjected to tooth extraction
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Angiogenesis Inhibitors
/
Bone Density Conservation Agents
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
Type of study:
Clinical_trials
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2016
Document type:
Article